Pure Strain Mice Born to Hybrid Mothers Following Ovarian Transplantation.
نویسندگان
چکیده
منابع مشابه
Effects of a hybrid maternal environment on brain growth and corpus callosum defects of inbred BALB/c mice: a study using ovarian grafting.
The corpus callosum of many but not all BALB/c mice is either abnormally small or absent. The basis for the defect is hereditary, but the proportion of mice expressing the anomaly can be modified by changing the early environment. The present study investigated the effects of an F1 hybrid maternal environment, which is known to promote better fetal development than an inbred environment, on bod...
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Background: Ovarian tissue transplantation is now considered as a procedure to preserve the fertility of young woman patient undergoing cancer therapy. An essential strategy to improve the efficiency of ovarian transplantation is to overcome the initial ischemia reperfusion injury and free radicals production that lead to a significant follicular loss. The aim of this study was to investigate t...
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In recent years, advances in the diagnosis and treatment of childhood, adolescent and adult cancer have significantly improved the survival rate and life expectancy of cancer patients. However, chemotherapy and radiotherapy treatments are gonadotoxic and may induce the loss of ovarian function and fertility with consequent premature ovarian failure (POF). A number of factors determine the level...
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BACKGROUND For women facing gonadotoxic treatment, cryopreservation of ovarian tissue with subsequent retransplantation during remission is a promising technique for fertility preservation. However, follicle loss within grafted ovarian tissue can be caused by ischemia and progressive revascularization. Several xenograft models using different immunodeficient rodent lines are suitable for studyi...
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Background: Ischemia and reperfusion after transplantation is the main problem which decreases follicular density in the grafted ovarian. Many sources of free radicals such as xanthine oxidase were generated during ischemia. In this study, we used allopurinol as xanthine oxidase inhibitor to reduce ischemia-reperfusion injury, to increase received oocytes and embryos, and to decrease Apoptosis ...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 31 9 شماره
صفحات -
تاریخ انتشار 1945